2021 head-to-head · Compact Car

2021 Audi A4 Hybrid vs Mercedes-Benz CLS-Class Hybrid

MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.

Swap sides
✓ Cheaper to run
$2,116/ year to fuel
28 MPG
✓ Cheaper to run
$2,279/ year to fuel
26 MPG

The 2021 Audi A4 Hybrid is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,116 a year to fuel (28 MPG), versus $2,279 for the 2021 Mercedes-Benz CLS-Class Hybrid (26 MPG). That's roughly $163 a year, or about $814 over five years.

Your numbers

Change these to match your driving and local prices. Every figure and chart on this page updates.

Fuel cost over 10 years

  • Audi A4 Hybrid
  • Mercedes-Benz CLS-Class Hybrid

Side by side

Audi A4 HybridMercedes-Benz CLS-Class Hybrid
$2,116 Your annual fuel cost $2,279
28 MPG Combined efficiency 26 MPG
25 MPG City 23 MPG
34 MPG Highway 30 MPG
92 cu ft Passenger volume 93 cu ft
12 cu ft Cargo volume 12 cu ft
311 g/mi Tailpipe CO₂ (g/mi) 347 g/mi
6/10 EPA fuel economy score 5/10
6/10 EPA greenhouse gas score 5/10
Hybrid Powertrain Hybrid
Premium gasoline Fuel Premium gasoline
2.0L 4-cyl turbo Engine / motor 3.0L 6-cyl turbo
7-speed dual-clutch Transmission 9-speed automatic
AWD Drivetrain RWD

✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.

Audi A4 Hybrid vs Mercedes-Benz CLS-Class Hybrid across model years

  • Audi A4 Hybrid
  • Mercedes-Benz CLS-Class Hybrid

Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.

How they differ

Among 37 2021 compact cars, the Audi A4 Hybrid ranks 22nd and the Mercedes-Benz CLS-Class Hybrid 28th for lowest fuel cost.

Frequently asked questions

Which is more fuel-efficient, the 2021 Audi A4 Hybrid or the 2021 Mercedes-Benz CLS-Class Hybrid?

Measured by cost to drive, the Audi A4 Hybrid. The Audi A4 Hybrid is rated 28 MPG combined and the Mercedes-Benz CLS-Class Hybrid 26 MPG (EPA, most efficient configuration of each).

How much does it cost to fuel the 2021 Audi A4 Hybrid vs. the Mercedes-Benz CLS-Class Hybrid per year?

At 15,000 miles a year with $3.95/gal premium gas, about $2,116 for the Audi A4 Hybrid and $2,279 for the Mercedes-Benz CLS-Class Hybrid.

Audi A4 Hybrid vs Mercedes-Benz CLS-Class Hybrid in other years

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