2023 head-to-head · Midsize Car

2023 Audi S6 Hybrid vs Mercedes-Benz E-Class

MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.

Swap sides
✓ Cheaper to run
$2,693/ year to fuel
22 MPG

AWD · 2.9L 6-cyl turbo · 8-speed automatic · 22 MPG

✓ Cheaper to run
$2,279/ year to fuel
26 MPG

The 2023 Mercedes-Benz E-Class is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,279 a year to fuel (26 MPG), versus $2,693 for the 2023 Audi S6 Hybrid (22 MPG). That's roughly $414 a year, or about $2,072 over five years.

Your numbers

Change these to match your driving and local prices. Every figure and chart on this page updates.

Fuel cost over 10 years

  • Audi S6 Hybrid
  • Mercedes-Benz E-Class

Side by side

Audi S6 HybridMercedes-Benz E-Class
$2,693 Your annual fuel cost $2,279
22 MPG Combined efficiency 26 MPG
19 MPG City 23 MPG
26 MPG Highway 31 MPG
99 cu ft Passenger volume 98 cu ft
14 cu ft Cargo volume 13 cu ft
408 g/mi Tailpipe CO₂ (g/mi) 342 g/mi
5/10 EPA fuel economy score 5/10
5/10 EPA greenhouse gas score 5/10
Hybrid Powertrain Gas
Premium gasoline Fuel Premium gasoline
2.9L 6-cyl turbo Engine / motor 2.0L 4-cyl turbo
8-speed automatic Transmission 9-speed automatic
AWD Drivetrain RWD

✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.

Audi S6 Hybrid vs Mercedes-Benz E-Class across model years

  • Audi S6 Hybrid
  • Mercedes-Benz E-Class

Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.

How they differ

Per EPA interior volume figures, the Audi S6 Hybrid has more cargo space (14 vs. 13 cu ft).

Among 50 2023 midsize cars, the Audi S6 Hybrid ranks 45th and the Mercedes-Benz E-Class 36th for lowest fuel cost.

The powertrains differ: the Audi S6 Hybrid is a full hybrid, while the Mercedes-Benz E-Class is a conventional gas model.

Frequently asked questions

Which is more fuel-efficient, the 2023 Audi S6 Hybrid or the 2023 Mercedes-Benz E-Class?

Measured by cost to drive, the Mercedes-Benz E-Class. The Audi S6 Hybrid is rated 22 MPG combined and the Mercedes-Benz E-Class 26 MPG (EPA, most efficient configuration of each).

How much does it cost to fuel the 2023 Audi S6 Hybrid vs. the Mercedes-Benz E-Class per year?

At 15,000 miles a year with $3.95/gal premium gas, about $2,693 for the Audi S6 Hybrid and $2,279 for the Mercedes-Benz E-Class.

Which has more cargo space?

The Audi S6 Hybrid, with 14 cu ft of luggage volume versus 13 cu ft (EPA interior volume index).

Audi S6 Hybrid vs Mercedes-Benz E-Class in other years

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