2025 head-to-head · Compact Car
2025 Audi S4 vs Lexus IS
MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.
AWD · 3.0L 6-cyl turbo · 8-speed automatic · 24 MPG
The 2025 Lexus IS is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,370 a year to fuel (25 MPG), versus $2,469 for the 2025 Audi S4 (24 MPG). That's roughly $99 a year, or about $494 over five years.
Your numbers
Change these to match your driving and local prices. Every figure and chart on this page updates.
Fuel cost over 10 years
- Audi S4
- Lexus IS
Side by side
| Audi S4 | Lexus IS | |
|---|---|---|
| $2,469 | Your annual fuel cost | $2,370 |
| 24 MPG | Combined efficiency | 25 MPG |
| 20 MPG | City | 21 MPG |
| 29 MPG | Highway | 31 MPG |
| 92 cu ft | Passenger volume | 90 cu ft |
| 12 cu ft | Cargo volume | 11 cu ft |
| 377 g/mi | Tailpipe CO₂ (g/mi) | 356 g/mi |
| 5/10 | EPA fuel economy score | 5/10 |
| 5/10 | EPA greenhouse gas score | 5/10 |
| Gas | Powertrain | Gas |
| Premium gasoline | Fuel | Premium gasoline |
| 3.0L 6-cyl turbo | Engine / motor | 2.0L 4-cyl turbo |
| 8-speed automatic | Transmission | 8-speed automatic |
| AWD | Drivetrain | RWD |
✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.
Audi S4 vs Lexus IS across model years
- Audi S4
- Lexus IS
Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.
How they differ
Per EPA interior volume figures, the Audi S4 has more cargo space (12 vs. 11 cu ft).
Among 26 2025 compact cars, the Audi S4 ranks 21st and the Lexus IS 19th for lowest fuel cost.
Frequently asked questions
Which is more fuel-efficient, the 2025 Audi S4 or the 2025 Lexus IS?
Measured by cost to drive, the Lexus IS. The Audi S4 is rated 24 MPG combined and the Lexus IS 25 MPG (EPA, most efficient configuration of each).
How much does it cost to fuel the 2025 Audi S4 vs. the Lexus IS per year?
At 15,000 miles a year with $3.95/gal premium gas, about $2,469 for the Audi S4 and $2,370 for the Lexus IS.
Which has more cargo space?
The Audi S4, with 12 cu ft of luggage volume versus 11 cu ft (EPA interior volume index).
Audi S4 vs Lexus IS in other years
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