2025 head-to-head · Midsize Car
2025 Audi S6 Hybrid vs Lexus LS Hybrid
MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.
AWD · 2.9L 6-cyl · 8-speed automatic · 22 MPG
AWD · 3.5L 6-cyl · CVT · 25 MPG
The 2025 Lexus LS Hybrid is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,370 a year to fuel (25 MPG), versus $2,693 for the 2025 Audi S6 Hybrid (22 MPG). That's roughly $323 a year, or about $1,616 over five years.
Your numbers
Change these to match your driving and local prices. Every figure and chart on this page updates.
Fuel cost over 10 years
- Audi S6 Hybrid
- Lexus LS Hybrid
Side by side
| Audi S6 Hybrid | Lexus LS Hybrid | |
|---|---|---|
| $2,693 | Your annual fuel cost | $2,370 |
| 22 MPG | Combined efficiency | 25 MPG |
| 19 MPG | City | 22 MPG |
| 27 MPG | Highway | 29 MPG |
| 99 cu ft | Passenger volume | 99 cu ft |
| 14 cu ft | Cargo volume | 12 cu ft |
| 408 g/mi | Tailpipe CO₂ (g/mi) | 358 g/mi |
| 5/10 | EPA fuel economy score | 5/10 |
| 5/10 | EPA greenhouse gas score | 5/10 |
| Hybrid | Powertrain | Hybrid |
| Premium gasoline | Fuel | Premium gasoline |
| 2.9L 6-cyl | Engine / motor | 3.5L 6-cyl |
| 8-speed automatic | Transmission | CVT |
| AWD | Drivetrain | AWD |
✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.
Audi S6 Hybrid vs Lexus LS Hybrid across model years
- Audi S6 Hybrid
- Lexus LS Hybrid
Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.
How they differ
Per EPA interior volume figures, the Audi S6 Hybrid has more cargo space (14 vs. 12 cu ft).
Among 42 2025 midsize cars, the Audi S6 Hybrid ranks 38th and the Lexus LS Hybrid 33rd for lowest fuel cost.
Frequently asked questions
Which is more fuel-efficient, the 2025 Audi S6 Hybrid or the 2025 Lexus LS Hybrid?
Measured by cost to drive, the Lexus LS Hybrid. The Audi S6 Hybrid is rated 22 MPG combined and the Lexus LS Hybrid 25 MPG (EPA, most efficient configuration of each).
How much does it cost to fuel the 2025 Audi S6 Hybrid vs. the Lexus LS Hybrid per year?
At 15,000 miles a year with $3.95/gal premium gas, about $2,693 for the Audi S6 Hybrid and $2,370 for the Lexus LS Hybrid.
Which has more cargo space?
The Audi S6 Hybrid, with 14 cu ft of luggage volume versus 12 cu ft (EPA interior volume index).
Audi S6 Hybrid vs Lexus LS Hybrid in other years
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