2026 head-to-head · Midsize Car
2026 Audi S5 vs Lexus LS
MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.
AWD · 3.0L 6-cyl turbo · 7-speed dual-clutch · 23 MPG
AWD · 3.4L 6-cyl turbo · 10-speed automatic · 21 MPG
The 2026 Audi S5 is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,576 a year to fuel (23 MPG), versus $2,821 for the 2026 Lexus LS (21 MPG). That's roughly $245 a year, or about $1,227 over five years.
Your numbers
Change these to match your driving and local prices. Every figure and chart on this page updates.
Fuel cost over 10 years
- Audi S5
- Lexus LS
Side by side
| Audi S5 | Lexus LS | |
|---|---|---|
| $2,576 | Your annual fuel cost | $2,821 |
| 23 MPG | Combined efficiency | 21 MPG |
| 20 MPG | City | 17 MPG |
| 29 MPG | Highway | 27 MPG |
| 91 cu ft | Passenger volume | 99 cu ft |
| 22 cu ft | Cargo volume | 13 cu ft |
| 386 g/mi | Tailpipe CO₂ (g/mi) | 434 g/mi |
| 5/10 | EPA fuel economy score | 4/10 |
| 5/10 | EPA greenhouse gas score | 4/10 |
| Gas | Powertrain | Gas |
| Premium gasoline | Fuel | Premium gasoline |
| 3.0L 6-cyl turbo | Engine / motor | 3.4L 6-cyl turbo |
| 7-speed dual-clutch | Transmission | 10-speed automatic |
| AWD | Drivetrain | AWD |
✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.
Audi S5 vs Lexus LS across model years
- Audi S5
- Lexus LS
Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.
How they differ
Per EPA interior volume figures, the Lexus LS has more passenger space (99 vs. 91 cu ft); the Audi S5 has more cargo space (22 vs. 13 cu ft).
Among 31 2026 midsize cars, the Audi S5 ranks 27th and the Lexus LS 30th for lowest fuel cost.
Frequently asked questions
Which is more fuel-efficient, the 2026 Audi S5 or the 2026 Lexus LS?
Measured by cost to drive, the Audi S5. The Audi S5 is rated 23 MPG combined and the Lexus LS 21 MPG (EPA, most efficient configuration of each).
How much does it cost to fuel the 2026 Audi S5 vs. the Lexus LS per year?
At 15,000 miles a year with $3.95/gal premium gas, about $2,576 for the Audi S5 and $2,821 for the Lexus LS.
Which has more cargo space?
The Audi S5, with 22 cu ft of luggage volume versus 13 cu ft (EPA interior volume index).
Audi S5 vs Lexus LS in other years
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