2027 head-to-head · Midsize & Large SUV

2027 Infiniti QX65 vs Mercedes-Benz GLS-Class Hybrid

MPG, range and what each one really costs you to fuel, from official EPA ratings and recalculated with your own gas and electricity prices.

Swap sides
✓ Cheaper to run
$2,693/ year to fuel
22 MPG

AWD · 2.0L 4-cyl turbo · 9-speed automatic · 22 MPG

✓ Cheaper to run
$2,821/ year to fuel
21 MPG

AWD · 3.0L 6-cyl turbo · 9-speed automatic · 21 MPG

The 2027 Infiniti QX65 is the cheaper one to run. Driving 15,000 miles a year with $3.95/gal premium gas, it costs about $2,693 a year to fuel (22 MPG), versus $2,821 for the 2027 Mercedes-Benz GLS-Class Hybrid (21 MPG). That's roughly $128 a year, or about $641 over five years.

Your numbers

Change these to match your driving and local prices. Every figure and chart on this page updates.

Fuel cost over 10 years

  • Infiniti QX65
  • Mercedes-Benz GLS-Class Hybrid

Side by side

Infiniti QX65Mercedes-Benz GLS-Class Hybrid
$2,693 Your annual fuel cost $2,821
22 MPG Combined efficiency 21 MPG
20 MPG City 19 MPG
26 MPG Highway 24 MPG
404 g/mi Tailpipe CO₂ (g/mi) 424 g/mi
4/10 EPA fuel economy score 4/10
4/10 EPA greenhouse gas score 4/10
Gas Powertrain Hybrid
Premium gasoline Fuel Premium gasoline
2.0L 4-cyl turbo Engine / motor 3.0L 6-cyl turbo
9-speed automatic Transmission 9-speed automatic
AWD Drivetrain AWD

✓ marks the better value. EPA scores run 1–10 (10 is best). Volumes come from the EPA interior volume index and aren't published for every body style.

Infiniti QX65 vs Mercedes-Benz GLS-Class Hybrid across model years

  • Infiniti QX65
  • Mercedes-Benz GLS-Class Hybrid

Annual fuel cost of the most efficient configuration of each model year, at your prices. Click a point to open that year.

How they differ

Among 58 2027 midsize & large SUVs, the Infiniti QX65 ranks 44th and the Mercedes-Benz GLS-Class Hybrid 48th for lowest fuel cost.

The powertrains differ: the Infiniti QX65 is a conventional gas model, while the Mercedes-Benz GLS-Class Hybrid is a full hybrid.

Frequently asked questions

Which is more fuel-efficient, the 2027 Infiniti QX65 or the 2027 Mercedes-Benz GLS-Class Hybrid?

Measured by cost to drive, the Infiniti QX65. The Infiniti QX65 is rated 22 MPG combined and the Mercedes-Benz GLS-Class Hybrid 21 MPG (EPA, most efficient configuration of each).

How much does it cost to fuel the 2027 Infiniti QX65 vs. the Mercedes-Benz GLS-Class Hybrid per year?

At 15,000 miles a year with $3.95/gal premium gas, about $2,693 for the Infiniti QX65 and $2,821 for the Mercedes-Benz GLS-Class Hybrid.

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